光动力疗法加上局部皮质类固醇治疗侵蚀性口腔平坦菌:一项随机临床试验
Zhenyuan Wang1, Ruru Shao2, Junjun Chen2
1Department of Stomatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Core Unit of National Clinical Research Center for Oral Diseases, Shanghai, China.
International dental journal
|January 25, 2026
概括
甲蓝介导光动力学疗法 (MB-PDT) 与局部皮质类固醇相结合,可为侵蚀性口腔平淡 (E-OLP) 提供卓越的疼痛缓解和治疗. 与单独使用皮质类固醇相比,这种联合治疗也显著减少了E-OLP复发.
科学领域:
- 口腔医学是指口腔医学.
- 皮肤病学 皮肤病学
- 光动力学疗法 光动力学疗法
背景情况:
- 侵蚀性口腔平坦 (E-OLP) 是一种慢性炎症状况,由于复发和恶性转变潜力,治疗具有挑战性.
- 目前对E-OLP的治疗方法通常提供有限的疗效和症状控制.
研究的目的:
- 评估甲蓝介导光动力学疗法 (MB-PDT) 与局部皮质类固醇结合用于E-OLP治疗的疗效和安全性.
- 在E-OLP患者中,比较MB-PDT加上三氨酸 (TA) 与单独TA的结果.
主要方法:
- 一个单中心,单盲,随机对照试验,涉及74名E-OLP患者.
- 患者被随机分为两个组:MB-PDT加0.1%TA,或局部单独TA.
- 衡量的主要结果是组间的临床疗效率.
主要成果:
- 与TA结合的MB-PDT与单独TA相比显示出显著更高的临床疗效率 (P = .006).
- 在MB-PDT组中,从第4周到第12周 (P < .01) 观察到疼痛减轻的显著改善 (数值评分表).
- 在12周的随访期内,MB-PDT组的复发率明显较低 (P = .038),没有报告任何不良事件.
结论:
- 结合局部皮质类固醇的MB-PDT是一种安全有效的E-OLP治疗方法.
- 这种组合疗法显示出优异的疼痛缓解,增强的病变愈合,并减少复发与局部皮质类固醇单独相比.
- 这些发现表明MB-PDT组合疗法是改善长期E-OLP管理和患者生活质量的有希望的选择.
相关概念视频
Clinical Trials
10.2K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.2K
Clinical Trials: Overview
4.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Statistical Software for Data Analysis and Clinical Trials
1.4K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.4K
COPD: Management Using Bronchodilators and Corticosteroids
769
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
769
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.5K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.5K
Trial and Error and Algorithm
403
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
403


