综合性多omics分析涉及胺代谢和PI3K-Akt通路在辐射诱导的肺损伤
Jun Qiu1, Xinpan Li2, Yi Fang3
1Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region 530021, PR China; Department of Oncology, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410006, PR China; Department of Oncology, Changsha County People's Hospital (Hunan Provincial People's Hospital Xingsha Campus), Changsha 410000, China.
Tissue & cell
|January 25, 2026
概括
辐射诱导肺损伤 (RILI) 涉及代谢和基因表达变化,这些变化汇聚在PI3K-Akt和脂酶D通路上. 肺微生物群失调与RILI相关,提供了新的治疗点.
科学领域:
- *研究辐射诱导肺损伤 (RILI) 的分子机制.
- * 采用多学科方法进行综合分析.
背景情况:
- *胸部放射治疗经常导致辐射诱导肺损伤 (RILI).
- *目前对RILI机制的理解有限,没有FDA批准的治疗方法.
- * 需要确定RILI的早期生物标志物和治疗策略.
研究的目的:
- *阐明RILI背后的关键分子路径和调节机制.
- * 为了确定RILI检测的潜在早期生物标志物.
- * 探索RILI的新型治疗干预措施.
主要方法:
- * 在小鼠RILI模型中分析代谢和转录基因变化.
- * 肺组织组织病理学评估 (H&E,马森染色) 的肺组织.
- * 基于液态染色体质谱学 (LC-MS) 的代谢学和转录学.
主要成果:
- *RILI肺部表现出红细胞排泄,炎症,纤维化和上皮损伤.
- *发现了186种不同丰富的代谢物 (纯素,甘氨酸/氨酸/氨酸代谢) 和180种不同表达的基因.
- *综合性分析显示PI3K-Akt和脂酶D信号通路的趋同,与肺微生物群失调有关.
结论:
- * RILI进展涉及代谢失调和影响PI3K-Akt和脂酶D通路的转录基因变化.
- * 肺微生物群失调与RILI有关,这表明它在病变发生过程中的作用.
- *已确定的途径和微生物群变化为早期RILI生物标志物发现和治疗策略提供了潜力.
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
5.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.4K
What is Metabolism?
131.5K
Overview
131.5K
Biological Effects of Radiation
17.7K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.7K
C4 Pathway and CAM
49.0K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.0K
Radiation: Applications
1.7K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
The average...
1.7K
Absorption of Radiation
1.2K
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
1.2K


