日本慢性阻塞性肺病患者手握强度:一项前性队列研究
Seiichi Kobayashi1, Manabu Ono1, Masatsugu Ishida1
1Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan.
Respiratory investigation
|January 25, 2026
概括
慢性阻塞性肺病 (COPD) 患者的手握强度 (HGS) 较低表明不良结果的风险较高. 这种简单的测量可以预测COPD患者的死亡率.
科学领域:
- 肺部医学 肺部医学
- 老年病的医生 老年病的医生
- 肌肉生理学 肌肉生理学
背景情况:
- 骨肌肉功能障碍在慢性阻塞性肺病 (COPD) 中很常见.
- 手握强度 (HGS) 是肌肉强度的可靠指标.
- 在COPD中HGS的预后价值需要进一步调查.
研究的目的:
- 评估HGS在日本COPD患者的预后意义.
- 评估低HGS与临床结果在5年期间之间的关联.
主要方法:
- 对300名日本COPD患者进行前性观察研究.
- 基于HGS的分层:低 (男性<28公斤,女性<18公斤) 与正常.
- 在5年内对患者特征,恶化和全因死亡率的评估.
主要成果:
- 29.7%的患者具有低HGS.
- 低HGS与较低的BMI,较差的肺功能,呼吸障碍增加和体力活动减少相关.
- 低HGS与所有原因死亡率显著增加的风险有关 (HR 1.79).
结论:
- 低HGS与COPD的不良临床结果有关.
- 高血压是COPD患者死亡率的有价值的预后标志物.
- 这一发现强调了评估肌肉力量在COPD管理中的重要性.
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