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丹德罗聚糖类通过抑制病原性ER压力-脂轴来改善酒精诱导的肝损伤

Jiawei Ling¹, Ziwei Han², Junjie Qiu¹

¹College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|January 25, 2026

概括

登德罗的多糖体通过向内质网膜应激 (ERS) - 脂轴,保护免受与酒精相关的肝病 (ALD) 的影响. 这种方法可以减少有毒胺的积累和炎症,为ALD提供了一种新的治疗策略.

科学领域:

肝病学和分子生物学
自然产品化学自然产品化学
药理学药理学是指药理学的学科.

背景情况:

酒精相关性肝病 (ALD) 是一个重要的全球健康挑战,具有复杂的,不完全理解的分子基础.
细胞内膜网膜应激 (ERS) 和脂代谢变化与ALD病变有关,但它们的直接联系仍然难以捉摸.

研究的目的:

调查丹德罗多糖 (DPs) 对ALD的保护作用.
阐明DPs调节ALD中的ERS-脂轴的机制.

主要方法:

建立一个GAO-binge小鼠模型用于ALD.
使用Dendrobium loddigesii Rolfe (DLP) 和Dendrobium officinale Kimura和Migo (DOP) 聚糖的方法.
使用综合性肝脏转录组学,代谢组学和脂质组学进行全面分析,通过qRT-PCR和西方 blot验证.

主要成果:

DPs显著减轻了酒精诱导的肝脏和肠道损伤,改善了关键的生化和组织学标志物,并减少了氧化应激.
多omics分析揭示了一个关键的"ERS-sphingolipid轴",其中酒精诱导的ERS促进有毒胺的积累.
在抑制ERS传感器 (PERK,IRE1α,ATF6) 方面,DLP表现出优于DOP的效果,使胺水平正常化并恢复脂平衡.

结论:

登德罗的多糖类通过破坏ERS-脂轴来保护ALD,从而减少脂毒性和炎症.
这项研究确定了ERS-sphingolipid轴作为ALD的关键病原性枢纽.
DPs代表了ALD治疗的有希望的治疗候选者,他们的作用得到了机械洞察的支持.

关键词:

与酒精有关的肝病 (ALD)丹德罗的多糖化物细胞内膜网膜应激 (ERS) 是一种压力.多个omics的多个omics.斯芬戈脂类的新陈代谢

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