在2018年至2023年期间,新兴的抗特比纳的Trichophyton indotineae:一项跨国基因组流行病学研究
Johanna Rhodes1, Sui Ting Hui2, Sarah Dellière3
1Medical Research Council Centre for Global Infectious Disease Analysis, Imperial College London, London, UK; Department of Medical Microbiology, Radboudumc, Nijmegen, Netherlands.
The Lancet. Microbe
|January 25, 2026
概括
新兴的Trichophyton indotineae由于遗传突变而表现出广泛的特比纳耐药性. 基因组监测对于在全球范围内管理这种快速传播,耐药性皮肤菌至关重要.
科学领域:
- 医学真菌学 医学真菌学
- 基因组流行病学 基因组流行病学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 三植物物种是全球皮肤植物病的主要原因.
- 三菌 (Trichophyton indotineae) 是一种新兴的病原体,表现出对特比纳的耐药性和快速传播.
- 了解T. indotineae的流行病学对于有效的治疗和控制至关重要.
研究的目的:
- 使用基因组方法来描述Trichophyton indotineae的流行病学.
- 调查T. indotineae分离物中特尔比纳耐药性的遗传基础.
- 评估这种新兴病原体的全球分布和进化起源.
主要方法:
- 来自英国,爱尔兰,法国,加拿大和印度的T. indotineae分离物 (2014-2023) 的回顾性基因组流行病学研究.
- 全基因组测序 (WGS) 用于确认90个T. indotineae分离物.
- 抗真菌敏感性测试 (AFST) 用于确定特比纳芬耐药性 (MIC ≥0.5 mg/L).
主要成果:
- 在90个T. indotineae分离物中,有63%显示出对特尔比纳芬的耐药性.
- 孤立物种之间高度的遗传特征表明,它们有一个单一的进化起源.
- 在SQLE (ERG1) 中非同义的SNP与特尔比纳耐药性有关,尽管也提出了替代机制.
结论:
- 印丁 (Trichophyton indotineae) 从亚洲的多样性中心迅速蔓延到各大洲.
- 没有明确的地理聚类表明广泛的跨大陆传播.
- 加强基因组监测对于管理这种严重的,新兴的,耐特巴纳芬皮肤菌的管理至关重要.
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