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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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系统性皮质类固醇治疗晚期癌症癌症相关疲劳:系统性审查和元分析
Akira Kuriyama1, Kikuko Miyazaki1, Sho Sasaki1
1Department of Health Informatics, Kyoto University Graduate School of Medicine and Public Health, Kyoto, Japan.
Journal of pain and symptom management
|January 25, 2026
概括
系统性皮质类固醇可以帮助减少与癌症相关的疲劳,并改善晚期癌症患者的生活质量. 有证据表明,它对疲劳,健康状况和食欲有好处,副作用最小,尽管确定性很低.
科学领域:
- 在瘤学瘤学.
- 抚慰性护理是一种缓解性护理.
- 临床药理学 临床药理学
背景情况:
- 与癌症相关的疲劳 (CRF) 显著降低了晚期癌症患者的生活质量.
- 系统性皮质类固醇经常被实证地用于管理CRF.
研究的目的:
- 系统评估系统性皮质类固醇对缓解晚期癌症成人患者CRF的疗效和安全性.
- 综合来自随机对照试验的证据在这个人群中使用皮质类固醇.
主要方法:
- 在Medline,Cochrane控制试验中央注册表和ClinicalTrials.gov.gov进行了全面的文献搜索.
- 包括随机对照试验,涉及患有晚期癌症的成人患者,患有CRF并且不符合治愈治疗的条件.
- 用随机效应模型分析数据,通过GRADE方法评估证据的确定性.
主要成果:
- 对6项研究 (379名参与者) 的分析显示,全身性皮质类固醇降低了CRF (SMD -0.41,低确定性).
- 总体健康状况 (SMD 0.34,低确定性) 和食欲 (SMD -0.37,低确定性) 均有所改善.
- 没有观察到不良事件的显著增加 (RR 1.17,低确定性).
结论:
- 系统性皮质类固醇显示出降低CRF并提高晚期癌症患者的全球健康状况和食欲的潜力.
- 观察到的好处似乎伴随着极小的不良事件的额外风险.
- 然而,所有调查结果都是基于低确定性证据,因此需要谨慎解释.
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