第二代抗精神病药物和青少年的现实世界结果,标签上和标签之外的指示
Le Zhang1, Patrick D Quinn2, Johan Bjureberg3
1Shenzhen University, Shenzhen, Guangdong, China; Karolinska Institute, Stockholm, Sweden.
Journal of the American Academy of Child and Adolescent Psychiatry
|January 25, 2026
概括
年轻人接受第二代抗精神病药物 (SGA) 治疗后,住院,自我伤害和暴力犯罪的风险降低. 风险总体上回到了基线,但仍然很高,对意外伤害率的影响很小.
科学领域:
- 儿童和青少年精神病学
- 药物监督 药物监督 药物监督
- 现实世界 证据研究 实证研究
背景情况:
- 全球第二代抗精神病药物 (SGA) 处方对青少年的增加.
- 对SGA对现实世界结果的影响的理解有限,特别是对于未经批准的指示.
研究的目的:
- 评估SGA治疗在全国青年队伍中的现实世界结果.
- 在SGA启动之前和之后检查精神病医院住院,自我伤害,意外伤害和暴力犯罪风险的变化.
主要方法:
- 在瑞典 (2007-2020年) 对21,306名年轻人 (7-17岁) 进行的国家队列研究.
- 在SGA启动前一年和之后的个人风险比较.
- 对长达13年的重复治疗进行分析,检查包括精神病,自闭症和多动症在内的各种迹象.
主要成果:
- 在SGA启动之前,精神病医院住院,自我伤害和暴力犯罪的风险增加,在治疗期间降低,尽管没有完全恢复到基线.
- 患有精神病相关疾病的年轻人显示出更高的启动前风险,并随后减少住院和自我伤害的风险.
- 神经发育障碍 (如ADHD) 显示暴力犯罪风险下降更大;意外伤害风险没有显著关联.
结论:
- 青少年SGA治疗与精神病医院住院,自伤和暴力犯罪风险在最初升级后的减少有关.
- 在SGA治疗期间观察到的风险降低并没有完全恢复到启动前的水平.
- 在这个队列中,SGA治疗与意外伤害风险没有显著关联.
相关概念视频
Indicators
59.9K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
59.9K
Psychosis and Antipsychotic Drugs: Overview
846
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
846
Antipsychotic Drugs: Therapeutic Uses and Side Effects
784
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
784
Predicting Reaction Outcomes
10.4K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.4K
Outcomes of Glycolysis
106.8K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
106.8K
Antipsychotic Drugs: Typical and Atypical Agents
800
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
800


