胰岛素样生长因子2 mRNA结合蛋白2 调节PINK1 通过m6表达促进BMSCs中粒的途径 缓解绝经后骨质疏松症

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Updated: Jan 27, 2026

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Yu Ji1, Yajun Cui1, Lingshuang Li1

  • 1Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China; Center of Osteoporosis and Bone Mineral Research, Shandong University, Jinan, China.

Free radical biology & medicine
|January 25, 2026
PubMed
概括

类似胰岛素的增长因子2 (IMP2) 缺陷加速骨质疏松症的骨损失,通过促进骨髓介质干细胞 (BMSC) 衰老. 通过m6A-PINK1-mitophagy通路,IMP2的损失会影响骨质生成.

关键词:
这就是BMSCs.在 IMP2 中,MP2 包含了 IMP2.标签:PINK1PINK1PINK1PINK1在PMOP中使用PMOP.m(6) A6) 一个衰老是一种老化.

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