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复制能力作为评估微生物对消毒剂敏感性的基础
A Kramer1, J K Knobloch2, J Gebel3
1Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Germany; Association for Applied Hygiene (VAH) e.V., Bonn, Germany.
The Journal of hospital infection
|January 25, 2026
概括
消毒剂使用后的微生物存活率不是临床相关的耐药性,因为没有使用后的临界复制能力 (RCAU) 被证实. 这一新标准确保了在现实条件下对消毒剂有效性的准确评估.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 消毒剂耐药性解释缺乏一致的定义和临床上有意义的值.
- 消毒后的微生物生存需要一个标准化的指标来评估临床相关性.
- 使用后复制能力 (RCAU) 的概念是为了弥补这个差距而引入的.
研究的目的:
- 提出并定义使用后复制能力 (RCAU) 作为评估消毒后微生物存活率的标准化终点.
- 通过RCAU框架重新评估有关消毒剂耐受性和耐药性的现有证据.
- 为了确定在建议的消毒剂使用条件下微生物生存是否构成临床相关的耐药性.
主要方法:
- 对关于常见消毒剂物质的已发表证据进行了系统审查.
- 根据RCAU定义重新评估结果,重点是应用度的定量悬浮试验.
- 该研究特别研究了报告的微生物存活率是否表明了关键的RCAU.
主要成果:
- 在标准化应用条件下,没有任何消毒剂组显示出关键的RCAU.
- 许多关于降低敏感性或存活率的报道并非基于使用度暂停试验,这阻碍了RCAU的解释.
- 虽然存在一些过渡性适应和已确定的抗性机制 (例如,三桑,银),但在标准化测试中,没有一个证实了关键的RCAU.
结论:
- RCAU提供了一个清晰的,基于使用条件的框架,以区分非关键生存时间和临床相关的耐药性.
- 目前的证据表明,在建议的消毒剂度下,没有关键的RCAU故障.
- 许多关于消毒剂耐药性的先前发现需要使用标准化悬浮试验和RCAU指标进行重新评估.
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