在白血病中循环生物标志物
Aiyun Dong1, Mehdi Jahedi Zargar2, Amirhossein Mirzazadeh3
1Department of Neurology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030001, China.
Clinica chimica acta; international journal of clinical chemistry
|January 25, 2026
概括
液体活检提供了一种不那么侵入性的方法来监测血液癌症,使用循环生物标志物,如无细胞DNA (cfDNA). 这些血液测试有助于追踪治疗的有效性,并比传统方法更早地检测复发.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
背景情况:
- 液体活检分析循环生物标志物 (cfDNA,ctDNA,miRNA,EVs) 以实时了解血液恶性瘤.
- 基于血液的测定方法比骨髓活检提供了序列采样优势,以捕捉时间变化和异质性.
研究的目的:
- 审查当前的技术,临床应用和白血病循环生物标志物的转化机会.
- 讨论阻碍这些生物标志物的临床实施的挑战.
主要方法:
- 审查当前用于生物标志物检测的高通量测序和数字PCR技术.
- 对临床研究的分析,将循环瘤DNA (ctDNA) 动力学与患者的结果相关联.
- 对测定标准化和低频变异的解释障碍的评估.
主要成果:
- 技术的进步提高了检测最小残留疾病 (MRD),克隆进化和耐药性突变的灵敏度.
- ctDNA动力学与淋巴状和髓状恶性瘤的无进展和整体存活率相关,这表明其作为治疗效益的早期代用品的潜力.
- 敏感性因疾病生物学而异,需要结合基于骨髓的MRD和白细胞测序等待标准化.
结论:
- 循环生物标志物对个性化治疗决策和血液恶性瘤早期复发检测具有前途.
- 测试的标准化,理解生物变异性和强大的解释框架对于临床整合至关重要.
- 在广泛采用之前,需要进一步的前性标准化,特别是对于ctDNA,与传统方法相结合.
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