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相关概念视频

Fetal Circulation01:14

Fetal Circulation

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Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
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Coronary Circulation01:21

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The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
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Overview of Pulmonary Circulation01:19

Overview of Pulmonary Circulation

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The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
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Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

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The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Retroviruses02:33

Retroviruses

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Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
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在白血病中循环生物标志物.

Aiyun Dong1, Mehdi Jahedi Zargar2, Amirhossein Mirzazadeh3

  • 1Department of Neurology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030001, China.

Clinica chimica acta; international journal of clinical chemistry
|January 25, 2026
PubMed
概括

液体活检提供了一种不那么侵入性的方法来监测血液癌症,使用循环生物标志物,如无细胞DNA (cfDNA). 这些血液测试有助于追踪治疗的有效性,并比传统方法更早地检测复发.

关键词:
循环生物标志物循环生物标志物在白血病中,白血病.液体活检液体活检最小残留性疾病 (MRD) 是一种残留性疾病.精密血液学 精密血液学

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科学领域:

  • 血液学 血液学 血液学
  • 在瘤学瘤学.
  • 分子诊断学 分子诊断学

背景情况:

  • 液体活检分析循环生物标志物 (cfDNA,ctDNA,miRNA,EVs) 以实时了解血液恶性瘤.
  • 基于血液的测定方法比骨髓活检提供了序列采样优势,以捕捉时间变化和异质性.

研究的目的:

  • 审查当前的技术,临床应用和白血病循环生物标志物的转化机会.
  • 讨论阻碍这些生物标志物的临床实施的挑战.

主要方法:

  • 审查当前用于生物标志物检测的高通量测序和数字PCR技术.
  • 对临床研究的分析,将循环瘤DNA (ctDNA) 动力学与患者的结果相关联.
  • 对测定标准化和低频变异的解释障碍的评估.

主要成果:

  • 技术的进步提高了检测最小残留疾病 (MRD),克隆进化和耐药性突变的灵敏度.
  • ctDNA动力学与淋巴状和髓状恶性瘤的无进展和整体存活率相关,这表明其作为治疗效益的早期代用品的潜力.
  • 敏感性因疾病生物学而异,需要结合基于骨髓的MRD和白细胞测序等待标准化.

结论:

  • 循环生物标志物对个性化治疗决策和血液恶性瘤早期复发检测具有前途.
  • 测试的标准化,理解生物变异性和强大的解释框架对于临床整合至关重要.
  • 在广泛采用之前,需要进一步的前性标准化,特别是对于ctDNA,与传统方法相结合.