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Updated: Jan 27, 2026

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Bifidobacterium breve和Lacto-N-neotetraose通过肠道微生物群衍生的酸盐来调节便秘性能和便秘小鼠的肠道屏障功能
Yi Shan1, Xiaoling Liu2, Wei Ma3
1School of Food Engineering, Harbin University, Harbin, 150086, China.
Journal of dairy science
|January 25, 2026
概括
Bifidobacterium breve和Lacto-N-neotetraose的组合通过增强肠道微生物群的多样性和粘液的产生来改善便秘. 这种协同效应依赖于微生物群衍生的酸盐来缓解便秘.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 便秘是一个重要的公共卫生问题,治疗选择有限.
- 双细菌 (B. breve) 和Lacto-N-neotetraose (LNnT) 在缓解便秘方面的作用尚未完全理解.
- 对B. breve和LNnT的潜在协同效应尚不清楚.
研究的目的:
- 研究B. breve和LNnT单独或组合对便秘的作用和机制.
- 阐明B. breve和LNnT在缓解便秘方面的协同作用潜力.
- 分析对肠道微生物群,粘液分泌和相关代谢物的影响.
主要方法:
- 使用了BALB/c小鼠,分为对照,LNnT,B. breve和B. breve+LNnT组.
- 评估排便,肠道粘液,肠道微生物组成和血清激素水平.
- 评估粘液相关蛋白质的基因表达和与代谢物相关的微生物群.
主要成果:
- B. breve+LNnT显著改善了胃肠道通行和便中的水含量.
- 组合疗法增加了肠道粘液的产生和与粘液相关的基因的表达.
- 丰富的有益的肠道微生物群 (例如Bifidobacterium,Roseburia) 和增加的酸盐和酸盐水平.
结论:
- B. breve 和 LNnT 在缓解便秘方面表现出协同作用.
- 组合疗法增强了肠道屏障功能,调节了肠道微生物群.
- 便秘的缓解取决于肠道微生物群,并与微生物群衍生的酸盐相关.
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