在Helicobacter pylori感染中评估益生菌单疗法:随机对照试验的元分析与试验序列分析
Vivek Mishra1, Debabrata Dash1, Aditya K Panda2
1Department of Biotechnology, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India.
Microbial pathogenesis
|January 25, 2026
概括
益生菌单一疗法在减少Helicobacter pylori殖民和改善肠道症状方面表现有前途,但根除率较低. 乳杆菌reuteri和4周的补充似乎最有效,尽管独立使用是有限的.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 基于证据的医学基于证据的医学.
背景情况:
- 杆菌 (H. pylori) 感染是一个重大的全球健康问题.
- 目前正在探索非抗生素干预措施来管理H. pylori的殖民化.
- 益生菌正在研究它们在H. pylori管理中的潜在作用.
研究的目的:
- 通过对随机对照试验 (RCT) 的元分析,评估益生菌在减少H. pylori殖民化的有效性.
- 评估益生菌对H. pylori根除率和胃肠道症状的影响.
- 确定特定益生菌菌株和补充时间对结果的影响.
主要方法:
- 在主要数据库 (PubMed,Scopus,Cochrane Library,Google Scholar) 进行了系统的文献搜索.
- 数据使用综合元分析 (CMA) 软件和试验序列分析 (TSA) 进行分析.
- 使用推评估,开发和评估 (GRADE) 框架来评估证据的确定性.
主要成果:
- 与安慰剂相比,涉及益生菌单一治疗的28项RCT显示,H. pylori殖民的显著减少 (RR = 1.712).
- 乳杆菌 reuteri 成为一个特别有效的菌株,四周的补充期显示出更强烈的效果.
- 虽然细菌负载 (13C-UBT) 显著下降,胃肠道症状适度改善,但整体H. pylori根除率仅为16.8%.
结论:
- 益生菌单疗法,特别是用L. reuteri,可以减少H. pylori的殖民,并缓解胃肠道症状.
- 作为H. pylori根除的独立疗法,益生菌的有效性是有限的,原因是根除率低和研究质量差异.
- 需要进一步高质量的研究来确定益生菌的最佳作用,可能作为H. pylori治疗方案中的辅助疗法.
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