加速度计测量休息活动节奏模式和参数与老年人心血管和全因死亡率的关联:基于人口的队列研究
Shuaijie Chen1, Qiong Su1, Ruming Shen1
1Cardiovascular Department, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; The Higher Educational Key Laboratory for Cardiovascular Disease of Fujian Province, Fuzhou, 350005, China; Clinical Research Center for Metabolic Heart Disease of Fujian Province, Fuzhou, 350005, China.
Experimental gerontology
|January 25, 2026
概括
休息活动节奏 (RAR) 模式显著影响老年人死亡风险. 像"晚间类型"这样的不良模式增加了死亡率,而稳定的节奏减少了死亡率,突出了早期干预的潜力.
科学领域:
- 老年学是指老年学的学科.
- 时间生物学 时间生物学
- 公共卫生 公共卫生
背景情况:
- 休息活动节奏 (RAR) 是昼夜系统衰老的关键指标.
- 在老年人中,RAR模式和死亡率之间的长期关联尚未得到充分理解.
研究的目的:
- 调查不同休息活动节律模式与老年人死亡率之间的关系.
- 确定与增加或减少死亡风险相关的特定RAR参数.
主要方法:
- 利用了来自国家健康和营养检查调查 (2011-2014) 的数据.
- 从手腕加速度计数据中推导出RAR参数.
- 使用高斯混合模型识别了四种RAR模式,并使用Cox模型分析了死亡风险.
主要成果:
- 分析包括1710名老年人 (≥60岁),平均随访时间为6.67年.
- 确定了四种RAR模式:"早晨类型"",早些时候类型"",延迟类型"和"晚上类型".
- "晚间类型"模式显示,心血管和全因死亡率的风险明显更高. 较高的日间稳定性和相对幅度与较低的死亡率有关,而较高的日内变异性与增加的死亡率相关.
结论:
- 休息活动节奏模式和参数是老年人死亡率的重要预测因素.
- 不良RAR模式与心血管和全因死亡率的增加有关.
- 对中断的RAR模式的早期检测和干预可能会改善老年人的长期健康结果.
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