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Updated: Jan 27, 2026

Cell-Type Specific Protein Purification and Identification from Complex Tissues Using a Mutant Methionine tRNA Synthetase Mouse Line
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一种致病的Isoleucyl-tRNA合成酶变体导致蛋白质复合体形成的改变和细胞应激反应

Han Gao1, Rasangi Tennakoon1, Felicia Pais Araújo1

  • 1Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.

The Journal of biological chemistry
|January 25, 2026
PubMed
概括

在Isoleucyl-tRNA合成酶 (IARS1) 中的突变可以通过影响蛋白质稳定性和复合物形成而导致疾病,而不仅仅是酶活性. 这会影响细胞应激反应,特别是在低血糖条件下.

关键词:
氨基酸-tRNA合成酶的氨基酸.综合应激反应综合应激反应聚氨酸合成酶复合体的复杂性神经发育障碍是一种神经发育障碍.这是一个tRNARNA.

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