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细胞核酸感应触发了I型干扰素通过Hippo激酶LATS1激活

Tim Nass¹, Anna D Reichardt², Saba R Aliyari³

¹Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

The Journal of biological chemistry

|January 25, 2026

概括

河马路径,特别是LATS1激酶,对于激活TBK1信号来说至关重要. 这种激活对于诱导I型干扰素 (IFN-I) 和对病毒感染进行有效的抗病毒反应至关重要.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
病毒学病毒学

背景情况:

天生的免疫检测细胞质中的病毒核酸,触发I型干扰素 (IFN-I) 生产.
IFN-I诱导依赖于通过TBK1激酶激活IRF3,但TBK1信号机制尚未完全理解.

研究的目的:

研究Hippo信号通路在细胞核酸感应和IFN-I诱导中的作用.
阐明病毒感染期间TBK1信号调节的机制.

主要方法:

使用LATS1和Lats1淘汰赛小鼠模型的药理抑制剂.
在细胞核酸刺激后评估了TBK1-IRF3信号活动和IFN-I诱导.
研究了LATS1和TBK1.1之间的相互作用.

主要成果:

病毒感染或细胞核酸激活Hippo路径.
对于TBK1-IRF3信号传递和IFN-I诱导,需要LATS1激酶.
由于LATS1缺乏,导致病毒标位增加.
LATS1与TBK1结合并促进其酶活性.

结论:

希波/LATS1通路是TBK1信号的关键调节者,用于响应细胞核酸传感.
激活LATS1对于启动IFN-I抗病毒反应至关重要.
这项研究揭示了Hippo途径与先天抗病毒免疫力之间的新联系.

关键词:

河马的信号传递大型瘤抑制剂1 (LATS1)坦克结合激酶1 (TBK1) 的作用.天生的抗病毒信号传递.干扰素调节因子3 (IRF3)模式识别受体 (PRRs) 是一种第一种类型的干扰素 (IFN-I)

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