莱克通路的激活在长期COVID中推动了持续的补充失调
Samuel B K Keat1, Priyanka Khatri2, Youssif M Ali2,3
1Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
Immunology
|January 25, 2026
概括
长期的COVID与补充失调有关,特别是莱克通路. 较高的曼南结合性莱克相关血清蛋白酶-2 (MASP-2) /C1Inh复合体表明长期COVID患者的莱克通路激活.
科学领域:
- 免疫学 免疫学 免疫学
- 补充系统生物学 补充系统生物学
- 传染病病理生理学 传染病病理生理学
背景情况:
- 长期COVID,一种影响SARS-CoV-2幸存者的疾病,呈现出各种影响生活质量的症状.
- 慢性炎症和补体系统失调与长期COVID的病因有关.
- 之前的研究指出,长期COVID患者的补充通路激活标志物升高.
研究的目的:
- 调查长期COVID中莱克补充通路的作用.
- 通过补充分析来识别长期COVID的潜在生物标志物.
- 在长期COVID患者中分析曼南结合性莱克相关血清蛋白酶-2 (MASP-2) /C1Inh复合体.
主要方法:
- 对159名长期COVID患者和76名健康康复者的队列中MASP-2/C1Inh复合物的分析.
- 整合数据与其他预测补充分析.
- 应用通用线性建模和接收机操作特征 (ROC) 分析.
主要成果:
- 在长期COVID患者中,MASP-2/C1Inh复合体显著升高 (p=0.0003).
- 一组最佳生物标志物 (iC3b,TCC,MASP-2/C1Inh,properdin) 实现了0.796.79的ROC预测功率.
- 经典补充路径标记物对长期COVID的预测价值不佳.
结论:
- 莱克补充通路的激活是长期COVID的重要特征.
- 莱克通路,在替代和终端通路的上游,是一个潜在的治疗目标.
- 补充标记物的组合可以有效地预测长期COVID状态.
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