疾病活动的生物标志物在炎症性肠病中的疾病活动
Jalpa Devi1, Sami Samaan2, Gaurav Syal3
1Division of Gastroenterology and Hepatology, University of Nebraska Medical Center, S 42nd &, Emile Street, Omaha, NE 68198, USA; John T. Milliken Department of Medicine, Division of Gastroenterology, Washington University School of Medicine in St. Louis, 660 South Euclid Avenue, Campus Stop 8124, Saint Louis, MO 63110, USA.
本摘要指导临床医生使用生物标志物监测进行个性化炎症性肠病 (IBD) 护理. 它更新了血液,便和成像生物标志物,用于评估克罗恩病和性结肠炎的疾病活性.
科学领域:
- 胃肠病学和肝病学
- 临床诊断 临床诊断 临床诊断
- 个性化医疗是个性化的医疗.
背景情况:
- 炎症性肠病 (IBD) 管理需要准确的疾病活动评估.
- 生物标志物引导的治疗到目标策略越来越多地被认可为优化IBD护理.
- 个性化治疗方法对于改善IBD患者的治疗结果至关重要.
研究的目的:
- 为临床医生提供一本关于基于生物标志物的IBD监测的最新指南.
- 详细介绍已建立和新兴的生物标志物,用于评估克罗恩病和性结肠炎的疾病活性.
- 支持应用生物标志物引导的治疗到目标策略,符合STRIDE II共识.
主要方法:
- 关于既有和新兴生物标志物的综合文献综述.
- 专注于血液,便和放射性标记物,以评估疾病活动.
- 包括特殊群体和术后复发检测.
主要成果:
- 在IBD中监测疾病活动的关键生物标志物的摘要.
- 关于在治疗到目标框架内应用这些生物标志物的指导.
- 考虑特定的患者群体,包括患有大肠口袋,口,围抽性克罗恩病和怀孕的患者.
结论:
- 以生物标志物为指导的监测对于个性化,基于证据的IBD护理至关重要.
- STRIDE II共识支持一种以生物标志物为导向的IBD治疗到点的方法.
- 有效的监测策略对于在不同患者群体和疾病状态中管理IBD至关重要.
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