胰腺恶性和非恶性疾病的生物标志物
Jonathan M Downie1, Krystal Mills2, Shounak Majumder2
1Division of Gastroenterology and Hepatology, Department of Medicine, Massachusetts General Hospital, 15 Parkman Street, Wang 5, Boston, MA 02114, USA.
Gastroenterology clinics of North America
|January 25, 2026
概括
本综述涵盖了胰腺疾病的现有和新兴生物标志物,包括癌症和非癌症. 新的基于分子和流体的诊断方法显示出早期检测和更好的患者风险评估的前景.
科学领域:
- 胃肠病学和肝病学
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 胰腺疾病,包括恶性瘤和非恶性疾病,存在重大诊断挑战.
- 目前的诊断方法往往缺乏早期和准确检测的灵敏度和特异性.
- 需要改进的生物标志物来帮助临床决策.
研究的目的:
- 为胰腺疾病的现有和新生物标志物提供全面的概述.
- 评估目前胰腺疾病生物标志物的临床实用性和局限性.
- 讨论胰腺疾病的新兴诊断技术.
主要方法:
- 对胰腺疾病当前和新兴生物标志物的文献综述.
- 对已知生物标志物的临床实用性和局限性的分析.
- 探索分子,遗传和基于流体的诊断方法的进步.
主要成果:
- 胰腺疾病的现有生物标志物已经证明了不同的临床实用性和局限性.
- 新兴的基于分子,遗传和流体的诊断方法显示了改善检测和分层的巨大潜力.
- 新型生物标志物对于提高早期诊断和风险评估至关重要.
结论:
- 改进的生物标志物对于促进胰腺疾病的早期检测和风险分层至关重要.
- 未来的研究应该专注于验证和将新型诊断工具纳入临床实践.
- 增强的生物标志物发现将显著影响患者在恶性和非恶性胰腺疾病的结果.
相关概念视频
Pancreas
2.2K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
2.2K
Cells and Secretions of the Pancreas
4.8K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
4.8K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
840
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
840
Inflammatory Bowel Disease II: Crohn's Disease
1.0K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.0K
Immunodeficiency Diseases
2.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.0K
Principles of Disease Surveillance
488
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
488


