多作为巨细胞极化调节剂:慢性炎症疾病的机制和治疗潜力
Hui Huang1, Biying Fan2, Changhong Wei3
1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Phytotherapy research : PTR
|January 25, 2026
概括
自然的多醇通过关键信号通路调节巨细胞极化. 它们促进慢性疾病的抗炎M2偏振和癌症免疫治疗的亲炎M1偏振,提供双重治疗潜力.
科学领域:
- 免疫学和药理学
- 分子生物学分子生物学
背景情况:
- 巨细胞两极分化 (M1/M2) 在慢性炎症疾病中至关重要.
- 天然多具有免疫调节性质.
- 针对巨细胞两极分化提供了治疗潜力.
研究的目的:
- 审查自然多醇如何影响巨细胞两极分化.
- 探索它们在慢性炎症和癌症中的治疗应用.
- 讨论克服多限制的策略.
主要方法:
- 关于科学网络和PubMed数据库的文献评论.
- 搜索术语包括"天然多","巨分化","信号通路"和"慢性炎症".
- 对聚醇对关键信号通路的影响的分析 (NF-κB,JAK/STAT,PI3K/Akt,Notch).
主要成果:
- 聚醇调节信号通路,以重编程巨细胞的两极分化.
- 它们主要诱导M2极化,解决慢性炎症性疾病 (动脉样硬化,代谢,神经退行性).
- 多也可以诱导M1极化,有利于癌症免疫治疗.
结论:
- 聚醇通过指导巨细胞两极化来表现出治疗的双重性.
- 它们对治疗慢性炎症和增强癌症免疫疗法充满希望.
- 像纳米技术这样的创新方法可以改善多的生物可用性和毒性概况.
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