气道中的NKX3.1:跨支气管细针吸气的诊断陷
Joseph Gillam1, Phillip McMullen1, Güliz A Barkan1
1Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, Illinois.
Journal of the American Society of Cytopathology
|January 25, 2026
概括
经常在良性肺细胞中发现NKX3.1,使前列腺癌诊断复杂化. 病理学家在跨支气管FNA标本中解释NKX3.1染色时必须谨慎,以避免误诊.
科学领域:
- 病理学 病理学 病理学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- NKX3.1是前列腺腺癌的关键标志物.
- 跨支气管FNA标本中的良性支气管上皮细胞 (BEC) 和血清性腺体 (SMG) 可以表达NKX3.1.1.
- 这种表达式可能会干扰转移性前列腺癌的准确诊断.
研究的目的:
- 调查NKX3.1核阳性在良性BEC和SMG中的流行率.
- 评估NKX3.1表达在非前列腺癌患者的横支气管FNA活检中的诊断影响.
主要方法:
- 从没有前列腺癌的患者获得的跨支气管肺质量 (TBLM) 和淋巴结 (TBLN) FNA标本的回顾性分析.
- 针对NKX3.1的免疫组织化学染色是在固定在甲中的,嵌入在中的标本上进行的.
- 在BEC和SMG中记录了核染色强度和分布,并与尸检肺部截面进行了比较.
主要成果:
- 在94.4%的尸检肺部截面中观察到NKX3.1核染色,在BEC和SMG中强度可变.
- 在患者样本中,77.1%显示NKX3.1核染色,包括60.8%的TBLM FNA和87.5%的TBLN FNA.
- SMG显示了分散的阳性,而BEC显示了焦点,可变的染色.
结论:
- NKX3.1经常表达在良性支气管元素中.
- 病理学家在解释跨支气管FNA的NKX3.1染色时应谨慎.
- 在良性肺组织中误解NKX3.1可能导致转移性前列腺腺癌的错误诊断.
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