在接受 levetiracetam 单一治疗的儿科患者中评估甲状腺功能和甲状腺体积
Damla Sel Çoban1, Nur Çalışkan2, Aycan Ünalp2
1Department of Pediatric, University of Health Sciences, Uz Children's Hospital, Dr. Behçet, İzmir, Turkey. damlasel1996@gmail.com.
European journal of pediatrics
|January 25, 2026
概括
抗发作药物莱维西拉对6个月以上儿童的甲状腺功能或体积没有显著影响. 短期使用似乎对甲状腺健康是安全的,尽管甲状腺体积标准偏差得分略有下降.
科学领域:
- 儿科神经学 儿科神经学
- 内分泌学 在内分泌学.
背景情况:
- 是一种常见的抗发作药物 (ASM),用于儿科,具有普遍有利的安全性.
- 关于 levetiracetam 对小儿甲状腺功能的特定影响的数据有限.
研究的目的:
- 为了评估甲状腺功能测试和超声波甲状腺体积的变化,在儿童中使用单一治疗 levetiracetam.
- 评估儿童患者甲状腺健康的 levetiracetam 的安全性.
主要方法:
- 一项前性单中心研究包括40名儿童 (3个月-18岁) 接受单一治疗.
- 甲状腺功能测试 (fT3,ft4,TSH,Anti-TPO,Anti-Tg) 和甲状腺体积在基线和6个月后被测量.
- 使用年龄调整标准偏差得分 (SDS) 分析数据.
主要成果:
- 在基线和6个月之间没有观察到FT3,FT4,TSH,Anti-TPO或Anti-Tg水平的统计学上显著差异.
- 甲状腺绝对体积没有显著变化.
- 甲状腺体积标准偏差得分 (SDS) 的统计学显著下降被注意到 (p=0.018).
结论:
- 六个月的 levetiracetam 单疗法没有显著改变儿童的甲状腺激素水平或自身抗体.
- 绝对甲状腺体积保持稳定,尽管甲状腺体积SDS的减少表明潜在的微妙变化.
- 在儿童患者中,短期使用 levetiracetam 似乎对甲状腺功能是安全的.
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