代谢功能障碍相关的脂肪性肝病和周围动脉疾病:关联和治疗考虑因素
Stergios A Polyzos1, Myrsini Orfanidou1, Jannis Kountouras2
1First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Current vascular pharmacology
|January 26, 2026
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和外围动脉疾病 (PAD) 经常并存并共享危险因素. 通过改变生活方式和解决并发症来管理这两种疾病,可以降低心血管风险.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 血管医学 血管医学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和外围动脉疾病 (PAD) 是普遍存在的,独立增加心血管风险.
- 了解MASLD和PAD之间的关联对于将MASLD视为多系统疾病至关重要.
研究的目的:
- 审查目前关于MASLD和PAD之间关联的临床证据.
- 探索这种关联的潜在治疗影响.
主要方法:
- 使用PubMed数据库进行了文献搜索.
主要成果:
- MASLD和PAD具有共同的风险因素和致病机制.
- 临床研究表明,MASLD和PAD之间存在关联,特别是肝硬化.
- 管理策略重叠,重点关注生活方式的改变和对两种疾病都有潜在的有益药物.
结论:
- 生活方式干预和共同并发性疾病 (肥胖,糖尿病,高血压,脂质失调) 的管理是同时患有MASLD和PAD的患者的优先事项.
- 针对MASLD和PAD预计将降低受影响个体心血管风险的增加.
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