禾中的针:液体活检在发现骨瘤中的精度
Anthony Nohra1, Guy Awad1, John Victor El Khoury1
1Faculty of Medicine, Saint Joseph University of Beirut, Riad El Solh, 11-5076, Lebanon.
Anti-cancer agents in medicinal chemistry
|January 26, 2026
概括
液体活检在诊断和监测骨瘤方面表现有前途,为传统活检提供了最少侵入性的替代方案. 为了在管理这些具有挑战性的癌症方面得到广泛的临床使用,需要进一步验证.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 生物标志物发现发现
背景情况:
- 骨瘤存在重大诊断和治疗挑战,特别是在晚期.
- 传统的活检是侵入性的,需要更少的侵入性替代品来监测疾病.
- 液体活检分析循环瘤细胞 (CTC),循环瘤DNA (ctDNA) 和细胞外囊泡 (EV) 以进行动态疾病评估.
研究的目的:
- 审查液体活检在诊断,预后和指导骨瘤治疗中的作用.
- 为了突出最近的分子进步和临床发现,在骨癌的液体活检.
- 评估CTCs,ctDNA和EVs作为骨瘤管理中的生物标志物的潜力.
主要方法:
- 一个结构化的PubMed文献叙事审查,截至2024年7月.
- 包括关于骨髓瘤,尤文瘤,肌肉瘤和肌肉瘤的研究.
- 专注于来自各种体液的CTC,ctDNA和EV的临床影响.
主要成果:
- 液体活检证明了骨瘤的高诊断准确性.
- 检测CTC显示高灵敏度 (高达98.6%) 与转移性疾病和复发相关.
- ctDNA分析发现了突变和复发指标 (高达97.4%的特异性).
- EV生物标志物 (miRNAs) 分化了亚型并预测了存活率;先进的技术实现了接近100%的准确性.
- EVRNA测序揭示了与转移性进展相关的融合事件.
结论:
- 液体活检具有很强的潜力,可以彻底改变骨瘤护理.
- 标准化和大规模研究对于临床采用至关重要.
- 这种方法为精确的疾病监测和治疗指导提供了一种最小侵入性的工具.
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