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在肠-大脑轴中雌激素的双向传播:临床前和临床研究的证据

Rishabh Chaudhary¹, Nitin Bansal², Sheenam Sharma¹

¹Department of Pharmacology, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India.

Current drug targets

|January 26, 2026

概括

更年期相关的雌激素损失通过改变肠道微生物群 (GM) 来破坏肠-大脑轴 (GBA). 调节转基因可能为经历GBA功能障碍的绝经后妇女提供治疗益处.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
微生物学微生物学

背景情况:

绝经后妇女的雌激素缺乏会显著影响肠-大脑轴 (GBA).
新出现的证据将更年期相关的雌激素损失与GBA功能障碍联系起来.
肠道功能障碍越来越被认为是导致GBA功能障碍的一个因素.

研究的目的:

审查临床和临床前证据,将雌激素缺乏引起的肠道失调与绝经后妇女的GBA功能障碍联系起来.
探索雌激素在调节GBA功能中的作用.
综合目前关于更年期,肠道微生物群和GBA之间的关系的发现.

主要方法:

进行了对科学数据库 (PubMed,谷歌学者等) 的文献调查. ) 的情况.
使用的关键词:雌激素,GBA,更年期,肠道失生症和肠道微生物群 (GM).
包括实验和观察研究来综合发现.

主要成果:

雌激素缺乏会改变肠道微生物群的组成和多样性.
肠道屏障功能受损和免疫反应失调 (T细胞,微质细胞) 与雌激素损失有关.
证据强烈地将更年期相关的雌激素损失与肠道微生物失衡和GBA功能障碍联系在一起,导致认知和情绪障碍.

结论:

雌激素-GBA相互作用对绝经后的健康至关重要.
通过植物雌激素调节肠道微生物群,显示出有前临床数据支持的治疗前景.
需要进一步的精心设计的人体研究来验证基于微生物群的干预措施,以治疗与雌激素缺乏有关的神经生理障碍.

关键词:

肠-大脑轴肠-大脑轴临床研究临床研究.雌激素雌激素雌激素是一种我们的肠道微生物群.绝经后. 绝经后.临床前研究临床前研究

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