结合三种长效注射抗精神病药物:一个案例系列
Ayşe Nur İnci Kenar1, Selin Balki Tekin2
1Department of Psychiatry, Faculty of Medicine, Pamukkale University, Denizli, Türkiye.
概括
本案例系列探讨了用于治疗耐药精神分裂症的三重长效注射抗精神病药物 (LAIA). 结果显示,四名患者的症状显著减少,功能改善,没有重大副作用.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 治疗指南缺乏使用多种长效注射抗精神病药物 (LAIA) 的证据.
- 治疗耐药精神分裂症 (TRS) 的管理带来了重大的临床挑战.
- 克洛扎宾不服药和对其他治疗缺乏反应需要使用替代策略.
研究的目的:
- 在四名精神分裂症患者中展示三重LAIA的临床经验.
- 在耐火病例中评估LAIA联合治疗的安全性和有效性.
主要方法:
- 追溯分析四名患有治疗耐药精神分裂症的患者的临床病史.
- 患者对克洛扎宾,ECT和双抗精神病治疗没有反应.
- 专注于三重LAIAs治疗期间的结果.
主要成果:
- 这四位患者都表现出精神病症状的减少.
- 观察到住院频率的减少.
- 在没有显著的不良影响的情况下,人们注意到日常功能和治疗坚持的改善.
结论:
- 三重LAIA疗法可能是选择治疗耐药精神分裂症患者的安全和有效选择.
- 在实施这种治疗方法时,密切的临床监测至关重要.
- 需要进行进一步的研究,以建立基于证据的指导方针,以便多次使用LAIA.
更多相关视频
12:00Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
13.3K
06:14Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
5.1K
相关概念视频
Forces Acting on Chromosomes
3.9K
During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis.
Microtubules and motor proteins exert two types of forces on...
Microtubules and motor proteins exert two types of forces on...
3.9K
Psychosis and Antipsychotic Drugs: Overview
846
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
846
Antipsychotic Drugs: Therapeutic Uses and Side Effects
784
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
784
Resistors In Series
6.1K
A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination.
In a series circuit, the...
In a series circuit, the...
6.1K
Series Resonance
787
The RLC circuit impedance is defined as the ratio of the supply voltage to the circuit current. Resonance in such a circuit occurs when the imaginary part of this impedance equals zero. This specific condition means that the inductive reactance is exactly equal to the capacitive reactance. The frequency at which this happens is known as the resonant frequency. Mathematically, the resonant frequency is inversely proportional to the square root of the product of the inductance (L) and capacitance...
787
Antipsychotic Drugs: Typical and Atypical Agents
800
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
800
