认知萨科佩尼亚:KORA-Age研究中的死亡率和健康衰老的患病率和风险
Marie-Theres Huemer1,2, Barbara Thorand1,3, Eva Grill3,4
1Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Journal of cachexia, sarcopenia and muscle
|January 26, 2026
概括
认知性sarcopenia,sarcopenia和认知障碍的共存,显著增加了老年人的死亡风险和残疾. 建议在那些可能患有肉症的人中早期查认知障碍.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 认知性sarcopenia,即sarcopenia和认知障碍的同时存在,在老年人群中越来越令人担忧.
- 假设这种情况在老年人中增加了不良健康结果的风险.
研究的目的:
- 调查认知性sarcopenia和不良结果之间的关联,包括死亡率和残疾,在老年一般人口中.
- 确定基于人口的队列中的认知性肉症及其组成部分的流行率.
主要方法:
- 该研究分析了来自KORA-Age队列的65-93岁的1055名参与者的数据.
- 使用EWGSOP 2018标准定义了肉症,并通过采访评估认知障碍.
- 死亡率和不良结果 (残疾,需要护理) 分别在12年和3年内被跟踪,使用回归模型.
主要成果:
- 大约50%的老年人可能患有皮症,表现出认知障碍,而没有皮症的老年人则为20%.
- 认知可能的萨科佩尼亚 (8.1%) 和认知确认的萨科佩尼亚 (3.3%) 被确定.
- 认知性sarcopenia显著增加了所有原因死亡率 (HR 1.95),心血管死亡率 (HR 1.64) 和残疾 (OR 6.12) 的风险.
结论:
- 这些发现突出了与认知性萨科佩尼亚相关的显著增加的风险,强调了其临床意义.
- 建议在可能患有肉症的老年人中对认知障碍进行查.
- 支持进一步研究两种条件的同时干预措施.
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