基于微生物组的CAR-T治疗响应在淋巴瘤的建模:从枪元基因组学测序的见解
相关实验视频
Updated: Jan 27, 2026

08:43
Metagenomic Analysis of Silage
Published on: January 13, 2017
19.0K
Rafael Hernani1, Eliseo Albert2, Carlos Hernani-Morales3,4
1Haematology Department, Hospital Clínico Universitario, INCLIVA Research Institute, Valencia, Spain.
European journal of haematology
|January 26, 2026
概括
肠道微生物组会影响癌症免疫治疗的结果. 特定的肠道细菌,如Alistipes senegalensis和Bifidobacterium longum与接受CAR-T细胞治疗的患者的毒性降低和生存率提高有关.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究的研究.
- 在瘤学瘤学.
背景情况:
- 肠道微生物群在免疫系统和癌症免疫治疗中发挥作用.
- 在CAR-T治疗中对微生物干预的临床数据有限.
研究的目的:
- 研究接受CAR-T治疗的患者的肠道微生物群组成和临床结果之间的关联.
- 为了确定预测治疗反应和毒性的特定微生物物种.
主要方法:
- 30名B细胞淋巴瘤患者在CAR-T疗法 (axi-cel或4-1BB产品) 之前和之后的便样本的Shotgun metagenomics测序 (SMS).
- 开发和评估25个基于微生物组的机器学习 (ML) 模型,用于预测治疗反应.
- 分析微生物物种,毒性,反应和生存之间的相关性.
主要成果:
- 之前的抗生素暴露或α多样性对结果没有显著的影响.
- 与健康对照人群相比,观察到患者的失生症,特别是在轴细胞治疗时.
- 阿尔斯蒂普斯塞内加拉尼斯种和阿尔斯蒂普斯恩德多尼种分别与神经毒性降低和生存率提高有关.
- Bifidobacterium longum与降低细胞因子释放综合征相关; B. adolescentis,B. bifidum,B. breve与较差的生存率相关.
- ML模型显示出强大的预测能力,使用六种细菌物种的小组识别了非响应者.
结论:
- 肠道微生物群的组成与CAR-T治疗的临床结果有关.
- 特定的细菌物种可以作为预测毒性和生存的生物标志物.
- 基于微生物组的策略有望提高CAR-T疗法的疗效.
相关概念视频
Modeling in Therapy
410
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
410
Per-Unit Sequence Models
442
An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
442
Cis-regulatory Sequences
11.6K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K
Gene Therapy
27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Group Therapy
410
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
410
Sanger Sequencing
773.9K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
773.9K

