在老年人中,基于血液的生物标志物和肉症指标
Aida Koni1, Alvaro Santos-Cuerva1, Mercedes Sotos-Prieto1,2,3,4
1Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Journal of cachexia, sarcopenia and muscle
|January 26, 2026
概括
慢性 (Pb) 暴露会导致老年人的症. 高血清和全血Pb水平与肌肉强度,质量和功能降低有关,血清Pb可能是一个更敏感的生物标志物.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 毒理学 毒理学 毒理学
背景情况:
- 慢性低水平 (Pb) 暴露是一个公共卫生问题,特别是在老年人中.
- 虽然Pb的神经毒性和心血管作用是众所周知的,但它对与年龄相关的肌肉骨衰退和肉症的影响不太清楚.
- 关于Pb暴露生物标志物和肉症的流行病学数据有限.
研究的目的:
- 调查环境暴露与老年人肉症指标之间的关联.
- 评估血清和全血水平作为肌肉骨衰老的生物标志物的有用性.
主要方法:
- 在四项基于人口的研究中,分析了11842名年龄≥60岁的参与者的数据.
- 评估肉类症指标,包括肌肉强度,质量和功能.
- 使用多变量回归和元分析估计血清和全血Pb水平和肉类之间的关联.
主要成果:
- 含量与住宅环境因素有关.
- 血清和全血Pb都显示了与肌肉强度,质量和功能的剂量依赖的反向关联.
- 血清Pb比全血Pb更强烈地与下肢结果和肉相关,而不是全血Pb.
结论:
- 环境中的暴露会对肌肉骨健康产生负面影响,并导致老年人患上肉症.
- 血清可能是肌肉骨衰老的比全血更敏感的生物标志物.
- 血清应在未来的研究和监测中考虑与年龄相关的肌肉骨衰退.
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