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卡尔蛋白蛋白是一种循环生物标志物,也是慢性阻塞性肺部疾病中萨尔科佩尼亚的潜在治疗标

Liwei Liao¹, Jiaye Li¹, Weidong Xu^1,2

¹National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Journal of cachexia, sarcopenia and muscle

|January 26, 2026

概括

高血清calprotectin水平预测慢性阻塞性肺病 (COPD) 患者的萨尔科佩尼亚. 一种calprotectin抑制剂, paquinimod,在治疗卷烟引起的骨肌肉功能障碍方面显示出有前途.

科学领域:

肺部医学肺部医学
炎症研究炎症研究
肌肉生理学肌肉生理学

背景情况:

萨科佩尼亚是慢性阻塞性肺病 (COPD) 的重要并发症,增加了死亡率.
系统性炎症,包括像calprotectin这样的分子,与COPD相关的骨肌肉功能障碍有关.
卡尔蛋白在COPD肉症中的确切作用尚不清楚.

研究的目的:

为了调查calprotectin在COPD相关的肉症中的参与.
评估血清中calprotectin水平作为COPD患者肉症的预测指标.
在肌肉功能障碍模型中评估calprotectin抑制剂的治疗潜力.

主要方法:

用ELISA测量了235名稳定的COPD患者的血清calprotectin.
肌肉的强度和功能通过手握,四头肌强度和坐立测试来评估.
帕基尼莫德是一种calprotectin抑制剂,用于研究小鼠的香烟 (CS) 诱导的肌肉功能障碍.

主要成果:

血清calprotectin与肌肉强度和厚度有负相关性.
在COPD患者中观察到较高的calprotectin水平,这些患者患有肉症 (p < 0.001).
帕基尼莫德治疗减少了CS暴露的小鼠的肌肉质量损失和弱点,抑制了炎症途径.

结论:

血清calprotectin水平准确地预测了COPD患者的肉症.
卡尔蛋白抑制剂帕基尼莫德显示出作为治疗CS诱导的骨肌肉功能障碍的潜力.

关键词:

慢性阻塞性肺病 (COPD) 是一种慢性阻塞性肺病.为了保护巴克林,我们采取了一些措施.这种类型的麻症是sarcopenia.

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