低剂量辅助甲基胺延长释放在精神分裂症患者的认知和功能上的有效性:一个随机的开放标签试验
Naista Zhand1,2, Ridha Joober3, Alain Labelle1,2
1Schizophrenia and Recovery Program, Royal Ottawa Mental Health Centre, Ottawa, Canada.
Journal of clinical psychopharmacology
|January 26, 2026
概括
低剂量甲基胺延长释放 (ER) 改善了精神分裂症患者的功能能力和认知能力. 治疗还可以减少症状的严重程度,而不会使精神病恶化,这表明潜在的治疗益处.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 临床药理学 临床药理学
- 认知科学 认知科学
背景情况:
- 认知障碍是精神分裂症的一个重大挑战,影响患者的功能和康复.
- 甲基胺延长释放 (ER) 已在ADHD的认知缺陷中显示出有效性,但其在精神分裂症中的作用不太清楚.
- 对于解决精神分裂症谱系障碍的认知和功能缺陷的干预措施有着至关重要的需要.
研究的目的:
- 研究低剂量甲基化物ER对成年精神分裂症患者认知和功能结果的影响.
- 评估甲基胺ER对功能能力,认知表现和症状严重性的影响.
- 为了解决管理精神分裂症相关认知障碍的治疗缺口.
主要方法:
- 一个为期8周的,开放的,随机的交叉试验,涉及24名患有精神分裂症谱系障碍的成年人.
- 参与者接受了甲基化物ER或常规治疗 (TAU) 4 周,随后是交叉期.
- 测量结果包括功能能力 (VRFCAT),认知能力 (BACS) 和症状严重程度 (PANSS).
主要成果:
- 在甲基化物治疗ER时,观察到功能能力显著改善 (VRFCAT).
- 特定的认知领域,包括符号编码和伦敦塔,在BACS上有所改善.
- 阳性和阴性症状量表 (PANSS-6) 的得分有所改善,特别是在妄想和社会退缩方面,没有精神病恶化.
结论:
- 低剂量甲基化物ER可能会增强精神分裂症患者的功能能力和认知功能.
- 这项研究表明,减少症状,包括妄想和社会退出,有潜在的益处.
- 由于研究设计,结果被谨慎解释,表明甲基化物ER作为精神分裂症的潜在辅助治疗.
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