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Updated: Jan 27, 2026

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
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致病变体ACTA2 激活热冲击因子1和增加光滑肌细胞中的胆固醇生物合成,导致早期动脉样硬化

Maura L Boerio1,2, Abhijnan Chattopadhyay1, Xue-Yan Duan1

  • 1Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (M.L.B., A.C., X.-Y.D., A.K., E.C.M., A.P., A.K.M., D.R., S.D., W.V.-T., S.P., D.M.M.).

Circulation. Genomic and precision medicine
|January 26, 2026
PubMed
概括

致病性ACTA2变种可以导致胸前大动脉疾病和早期发生的动脉样性心血管疾病 (ASCVD). 识别特定的变异和分子通路有助于预防ASCVD在受影响的个体.

关键词:
动因子 动因子动脉样硬化 动脉样硬化胆固醇 Ester 是一种胆固醇.冠状动脉疾病是一种冠状动脉疾病.热冲击转录因子 转录因子

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