在营养不良的情况下,埃克迪松介导的肠道生长有助于微生物群驱动的发育可塑性
Longwei Bai1, Stéphanie Bellemin1, Elodie Guillemot1
1Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieur de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon 1, 46 allée d'Italie, 69007 Lyon, France.
概括
肠道细菌 Lactiplantibacillus plantarum 在营养压力下促进多索菲拉幼虫的生长. 这是通过通过Ecdysone信号来增强中肠发育而发生的,表明微生物群驱动的发育可塑性.
科学领域:
- 发育生物学是发展生物学.
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 在发育过程中,器官和系统生长协调是至关重要的,尤其是在营养压力下.
- 肠道微生物群影响宿主发育和成熟,特别是在Drosophila幼虫营养不良期间.
研究的目的:
- 研究肠道微生物群如何在营养压力下协调器官生长.
- 为了阐明Lactiplantibacillus plantarum促进Drosophila适应性生长的机制.
主要方法:
- 用Gnotobiotic Drosophila模型来研究乳植物菌植物 (Lp) 殖民的影响.
- 幼虫中肠的转录基因分析确定了关键的信号通路.
- 功能分析评估了Ecdysone信号传递和Shade酶在细菌中介生长中的作用.
主要成果:
- 植物乳杆菌可以选择性地增强中肠生长,缓冲饮食限制的影响.
- 与Lp的结合诱导了幼虫中肠中的强有力的Ecdysone信号签名.
- 通过Shade和肠细胞Ecdysone受体活性将Ecdysone局部转化为20-hydroxyecdysone,这对于依赖Lp的生长至关重要.
结论:
- 肠道Ecdysone信号在微生物群驱动的发育可塑性中发挥着关键作用.
- 共生细菌调节局部类固醇信号,以微调生物体的生长和成熟.
- 这项研究揭示了一种新的宿主微生物相互作用机制,影响了在压力下发育的机制.
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