带有淋巴发泄的T细胞淋巴瘤:诊断挑战和基于细胞学的方法
Thanh Thao Nguyen1,2, Anh Dung Vu3,2,4, Sohsuke Yamada3,2
1Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, Japan. nguyenthanhthao121997@gmail.com.
Histology and histopathology
|January 26, 2026
概括
由于恶性细胞很少,诊断有血清性输液的血管免疫原型T细胞淋巴瘤 (AITL) 是一个挑战. 像液体样本上的下一代测序 (NGS) 等先进技术改善了检测,并引导了更少的侵入性诊断.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 细胞病理学 细胞病理学
背景情况:
- 血管免疫原性T细胞淋巴瘤 (AITL) 是一种具有不良预后的侵袭性淋巴瘤.
- 淋巴瘤血清溢出是一种罕见但显著的表现,特别是当淋巴结活检具有挑战性时.
- 在AITL中的输出往往是细胞贫乏和炎症丰富,复杂化非典型的T毛囊辅助 (TFH) 类型T细胞的细胞学诊断.
研究的目的:
- 审查病例报告和AITL系列的淋巴发泄.
- 专注于临床表现,细胞学特征,辅助研究和结果.
- 提出一种基于流体的诊断算法,用于AITL输液.
主要方法:
- 案例报告和小系列的叙述审查.
- 对临床表现,细胞学,免疫细胞化学 (ICC),流细胞计,EBER in situ杂交和下一代测序 (NGS) 的分析.
- 整合世界卫生组织 (WHO) 和国家综合癌症网络 (NCCN) 的指南.
主要成果:
- 患者通常是患有晚期疾病的老年人.
- 溢出是排泄的,体积小,并且在细胞学上瘤细胞贫乏.
- 辅助研究 (ICC,流细胞计,EBER,NGS) 增强了AITL表型识别和突变检测 (例如,RHOA G17V,TET2).
结论:
- 在AITL中,淋巴瘤溢出与短生存率有关.
- 提出了一个实用的基于流体的诊断算法,集成细胞学和辅助工具.
- 为了改善风险分层和治疗指导,需要标准化工作流程,液体活检,多组学和人工智能辅助细胞学.
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