多中心回顾评估在狗中使用冷血小板的使用情况
Sarah Nugen1, Rebecca A L Walton1, Ryan Smith2
1VCA West Los Angeles, Los Angeles, California, USA.
概括
淋化血小板 (LPs) 可以给出血的狗,不管是血栓细胞减小. 这项研究发现LP在各种疾病中是安全有效的,并发症最小,存活率相似.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 血液学 血液学 血液学
- 输血医学 输血医学
背景情况:
- 狗的出血带来了诊断和治疗方面的挑战.
- 淋化血小板 (LPs) 为血小板输血提供了一个潜在的解决方案.
- 关于LP的使用和狗患者的并发症的数据有限.
研究的目的:
- 描述冷凍血小板 (LP) 在狗中的使用和并發症.
- 评估LP在患有与血小板缩相关的出血和非血小板缩相关的出血的狗中的疗效.
- 报告接受LP的狗的输血前和输血后值和整体存活率.
主要方法:
- 在2018年至2022年期间进行的回顾性研究.
- 从两个大学兽医教学医院收集的数据.
- 分析了接受冷解血小板的68只狗.
主要成果:
- 35只狗因与血小板缩相关的出血而接受LP治疗;33只狗因与非血小板缩相关的出血而接受LP治疗.
- 患有血小板缺血的狗在LP给药前和后的血小板数量显著降低.
- 没有观察到包装细胞体积 (PCV),其他血液产品输血或存活到出院的显著差异;6%的狗出现并发症.
结论:
- 溶解血小板的管理是狗经历出血的一个可行的选择.
- 可以在与血小板缺血相关的和非血小板缺血相关的出血病例中使用LP.
- 进一步的研究可能会探索最佳的LP剂量和适应症.
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