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精神分裂症患者的谷氨抗氧化途径:与代谢综合征的关系
Irina A Mednova1, Yuliya V Shternis1, Elena G Kornetova1
1Tomsk National Research Medical Centre of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russian Federation.
概括
精神分裂症患者的代谢综合征 (MetS) 与改变的谷氨 (GSH) 代谢有关. 这项研究发现了GSH水平和相关酶活性的显著差异,表明MetS患者的失调.
科学领域:
- 生物化学 生物化学
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 精神分裂症经常与代谢综合征 (MetS) 一起发生.
- 这两种情况都与氧化应激有关.
- 谷氨 (GSH) 代谢在细胞抵抗氧化应激的防御中起着至关重要的作用.
研究的目的:
- 在精神分裂症和MetS患者中调查谷氨 (GSH) 代谢参数.
- 为了比较具有和没有MetS的精神分裂症患者之间的GSH水平和酶活性.
主要方法:
- 该研究包括60名精神分裂症和MetS患者,70名精神分裂症患者没有MetS.
- 测量了总GSH和氧化GSH (GSSG) 的血清度.
- 包括谷氨S转移酶 (GST) 在内的与GSH相关的酶的活性通过光谱测量来确定.
主要成果:
- 与那些没有MetS的精神分裂症患者相比,患有MetS的精神分裂症患者的总GSH和GSSG度显著更高.
- 降低的GSH与GSSG (rGSH/GSSG) 的比率在MetS.患者中明显较低.
- 在患有MetS的精神分裂症患者中,氨酸S转移酶 (GST) 活性显著升高.
结论:
- 精神分裂症患者的代谢综合征与谷氨代谢的显著失调有关.
- 这些发现突出了MetS,精神分裂症和氧化应激路径之间的相互作用.
- 需要进一步的研究来探索针对该患者群体的GSH代谢的治疗策略.
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