主观认知衰退中改变的大脑网络动态和功能连接:一个以边缘为中心的网络研究研究
Xiaofan Wei1,2, Baiwan Zhou1, Juanling Li1
1Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in aging neuroscience
|January 26, 2026
概括
主观认知衰退 (SCD) 显示了大脑网络动态的改变,特别是在高幅度状态下. 这些神经动力学变化可能成为早期检测认知衰退的新生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 主观认知衰退 (SCD) 代表了早期的认知障碍.
- 了解SCD的神经动力学基础对于早期诊断和干预至关重要.
研究的目的:
- 通过以边缘为中心的功能网络框架来研究SCD的神经动力学基础.
- 为了确定SCD的潜在成像生物标志物.
主要方法:
- 利用了211名SCD患者和210名健康对照者的休息状态功能磁共振成像 (fMRI) 数据.
- 基于边缘时间序列 (ETS) 协波动信号构建的高和低振幅网络.
- 应用图形理论和基于网络的统计 (NBS) 用于网络分析和与认知得分和APOE ε4基因型相关的发现.
主要成果:
- 与HC相比,SCD患者的峰值幅度降低,谷到谷持续时间 (TTD) 延长.
- 在SCD中观察到正常化聚类系数,特征路径长度,小世界性和全球效率的显著减少.
- 高幅度网络揭示了更广泛的脑部变化,并确定了与SCD相关的特定子网络.
结论:
- 边缘中心网络框架为SCD中的大脑网络改变提供了新的见解.
- 在SCD中识别的神经动力学变化和子网络有可能成为可靠的生物标志物,用于早期检测和表征认知衰退.
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