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在帕金森病中分离认知和运动对iADL困难的贡献

Rekha Ravikumar¹, Marta Statucka¹, Melanie Cohn^1,2

¹Krembil Brain Institute, Toronto Western Hospital UHN, Toronto, ON, Canada.

Frontiers in aging neuroscience

|January 26, 2026

概括

在帕金森病 (PD) 中,在日常活动中区分认知障碍与运动症状是具有挑战性的. 一个新的报告认知负担 (RCB) 评分有效地识别认知变化,即使有严重的运动症状.

科学领域:

神经科学是一个神经科学.
神经学神经学
认知科学认知科学

背景情况:

区分轻度认知障碍 (MCI) 和痴呆症依赖于影响日常生活工具活动 (iADLs) 的认知缺陷.
在帕金森病 (PD) 中,运动和认知症状使iADL独立性的评估复杂化.
现有的方法很难将认知因素对PD功能衰退的贡献分离出来.

研究的目的:

评价两种方法,以区分运动与认知对PDiADL限制的贡献.
引入和验证一个新的报告认知负担 (RCB) 评分,该评分来自扩展的功能活动问卷 (FAQ).
评估这些指标与认知状态之间的关系 (PD-MCI与PD-CN).

主要方法:

在深度大脑刺激之前,对283名PD患者的回顾性图表审查.
对标准化和扩展的FAQ评级,认知诊断和神经心理测试成绩的分析.
开发和验证RCB评分和修改的FAQ评分方法 (FAQ_Q).

主要成果:

患者和护理伙伴iADL限制归因往往优先考虑运动症状,即使是"认知"项目.
与PD-CN相比,PD-MCI患者的新RCB得分明显高于PD-MCI患者.
不管评级者,RCB与注意力和执行功能表现相关,而FAQ_Q并没有区分认知状态.

结论:

患者/护理伙伴iADL症状归因可能与先前的FAQ项目分类在晚期PD不一致.
RCB评分为检测PD中轻微的认知变化提供了一个敏感的指标,即使是严重的运动障碍.
RCB可能有助于对PD和其他神经退行性疾病的认知诊断.

关键词:

认知诊断是一种认知诊断.每天运行的日常功能.提供信息者问卷调查问卷神经心理评估神经心理评估自我报告问卷问卷.

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