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轨道视网母细胞瘤:从息到通过顺序多模式多学科治疗治愈 - 一个案例报告
Victoria Wen Wei Ng1, Darren Ngiap Hao Tan1, Miriam Santiago Kimpo2
1Ophthalmic Oncology Service, Department of Ophthalmology, National University Hospital, National University of Singapore, Singapore, Singapore.
Case reports in oncology
|January 26, 2026
概括
轨道视网母细胞瘤 (RB) 是一种具有挑战性的晚期癌症. 多式疗法,包括新辅助化疗和质子束疗法 (PBT),为高级轨道RB病例提供了改善的生存结果.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 轨道视网母细胞瘤 (RB) 是一种晚期癌症,在历史上预后不佳,死亡率高.
- 据报道,有限的成功治疗结果,导致许多发展中国家的息治疗.
- 多模式治疗方案正在出现,但需要进一步验证.
研究的目的:
- 介绍一例单边轨道视网膜母细胞瘤多式疗法成功的案例.
- 突出新辅助化疗和质子束疗法 (PBT) 在晚期病例中的疗效.
- 挑战与轨道RB相关的历史性不良预后.
主要方法:
- 一名患有单边功能轨道RB的6岁儿童接受了4次新辅助化疗.
- 实现了完整的瘤回归,随后是眼球核和组织病理学确认.
- 辅助质子束疗法 (PBT) 在轨道植入物放置后进行.
主要成果:
- 新辅助化疗导致轨道瘤的完整临床回归.
- 患者在核化,轨道植入和PBT后实现了无病生存.
- 多式联络方法证明了先进轨道RB的成功管理.
结论:
- 多模式组合疗法,包括新辅助化疗和PBT,显著改善了先进轨道RB的生存结果.
- 由于副作用减少和二次恶性瘤风险降低,PBT为传统放射疗法提供了优越的替代方案.
- 这一案例表明,先进的轨道RB可以通过量身定制的综合方法成功治疗,实现无病生存.
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