基于油的乳提取物配方的增强生物可用性:体外和人体研究
Karin Engelhart-Jentzsch1, Ann-Kathrin Gantenbein1, Christiane Schön1
1BioTeSys GmbH, Esslingen, Germany.
Food & nutrition research
|January 26, 2026
概括
一种新的油配方显著提高了乳提取物 (西利玛林) 的生物可用性. 这种基于脂的输送系统可以改善脂的吸收,有利于肝脏和心脏健康.
科学领域:
- 药理动力学和药物输送方法
- 营养学科学 营养学科学
- 胃肠病学 胃肠病学
背景情况:
- 乳 (Silybum marianum) 具有肝保护性质,但其活性化合物西利马林的水溶性较差.
- 限定的西利马林溶解度限制了其在口服后的溶解和生物利用性.
- 需要新的配方来克服这些局限性.
研究的目的:
- 为了研究鱼油配方中西利玛林的传输速率穿过上皮屏障.
- 在健康的参与者中评估基于油的配方的生物可用性.
- 评估基于脂的输送系统在提高脂性生物活性疗效方面的潜力.
主要方法:
- 在体外消化模拟和Caco-2表皮屏障输送试验.
- 在禁食条件下对健康参与者进行随机交叉设计研究.
- 基于油的乳提取剂与乳提取剂粉末的单次口服剂量.
主要成果:
- 与油粉相比,油配方增加了28%的西里宾的运输系数.
- 在油配方中,生物可用性显著提高 (P < 0.0001).
- 油配方导致了8.59倍更高的AUC ((0-8h) 和15.08倍更高的Cmax,吸收动力更快.
结论:
- 基于脂的输送系统,就像油配方一样,有效地提高了脂类化合物的生物可用性,如西利马林.
- 克里尔油和乳的组合提供了有益的营养素,包括西利宾,多不和脂肪酸 (PUFA) 和胆.
- 这种配方策略有望提高乳的肝脏和心脏健康支持功效.
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