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使用体外模型的前景,以了解免疫疗法诱导的细胞因子释放综合征

Ethan Perkins1,2, Christopher Cooper2, Emma Lund2

  • 1Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom.

Frontiers in immunology
|January 26, 2026
PubMed
概括

新的体外模型,如先进的细胞因子释放试验 (CRAs),对于预测免疫相关的不良事件至关重要. 这些方法改善了药物安全性测试和临床毒性管理,如细胞因子释放综合征 (CRS).

关键词:
不良结果路径 (AOP)临床相关性临床相关性细胞因子释放综合征 细胞因子释放综合征免疫毒理学 免疫毒理学微生理系统的微生理系统.器官在芯片上的器官

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