系统性炎症标志物的动态变化对肝移植后死亡率的预后意义:一个回顾性队列研究
Eun Jung Kim1,2, Darhae Eum1,2, Jin Ha Park1,2
1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
International journal of medical sciences
|January 26, 2026
概括
中性粒细胞与淋巴细胞比率 (NLR) 的动态变化预测了肝移植 (LT) 后的长期死亡率. 持续高的NLR表明预后更差,有助于识别高风险患者进行量身定制的术后护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植免疫学 移植免疫学
- 关键护理医学 关键护理医学
背景情况:
- 肝移植 (LT) 是对末期肝病的重要治疗方法,但具有重大风险.
- 系统性炎症的动态对于理解LT后的疾病进展和恢复至关重要.
研究的目的:
- 调查系统性炎症标志物的时间变化对LT后长期死亡率的预后影响.
- 评估中性粒细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR) 和血小板与淋巴细胞比率 (PLR) 对三年死亡率的预测性能.
主要方法:
- 对377名LT患者的回顾性分析.
- 在手术前和手术后 (21-90天) 评估NLR,MLR和PLR.
- 根据NLR轨迹 (正常,升高,正常化,持久) 和分析死亡率关联的分层划分成组.
主要成果:
- 中性粒细胞与淋巴细胞的比率 (NLR) 在预测死亡率方面表现出最高的准确性.
- 通过NLR分层的患者显示出显著的死亡率差异,风险从正常升高到持续升高逐步增加.
- 与正常组相比,正常化和持久性NLR组的死亡率更高,通风时间更长,ICU/住院时间更长.
结论:
- 系统性炎症的动态变化,特别是NLR轨迹,与LT后的长期死亡率密切相关.
- 对于风险分层来说,NLR是可靠和可访问的炎症标志物.
- 术前NLR升高预示着不良结果,术后持续升高意味着预后比正常化更差,指导患者管理.
相关概念视频
Cholesterol: Significance and Regulation
1.4K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.4K
The Significance of Membrane Transport
41.5K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
41.5K
Significance of Center of Mass
7.7K
The center of mass of an object is defined as the mass-weighted average position of all the particles that comprise the object. The significance of the center of mass of an object can be seen by looking at its dynamics. The time derivative of the center of mass gives its velocity, assuming that the object's mass remains constant over time. Furthermore, the total linear momentum of an object can be seen as the linear momentum of a single particle of the object's total mass moving with...
7.7K
Statistical Significance
21.3K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
21.3K
Significance Testing: Overview
12.7K
Significance testing is a set of statistical methods used to test whether a claim about a parameter is valid. In analytical chemistry, significance testing is used primarily to determine whether the difference between two values comes from determinate or random errors. The effect of a particular change in the measurement protocol, analyst, or sample itself can cause a deviation from the expected result. In the case of a suspected deviation/outlier, we need to be able to confirm mathematically...
12.7K
Significance of Displacement Current
5.8K
A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
5.8K


