炎症生物标志物与极端内动脉化有关
Dren Boshnjaku1,2,3, Igor Petrov1, Pranvera Ibrahimi4,5
1Medical Faculty Skopje 'Ss Cyril and Methodius/Skopje/North Macedonia.
红细胞与血小板比率 (RPR) 与缺血性中风患者的内脏动脉化有关. 较高的RPR水平也与中风后功能结果较差相关.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 炎症标志物和红细胞指数越来越多地被认为是脑血管疾病的潜在指标.
- 内动脉化 (IAC) 与缺血性中风有关,但其亚型和与特定血液标记物的关系需要进一步调查.
研究的目的:
- 调查炎症标记物,红细胞与血小板比率 (RPR) 和红细胞分布宽度 (RDW%) 与不同类型的IAC之间的关联.
- 评估这些标志物与缺血性中风结果严重程度之间的关系.
主要方法:
- 118名缺血性中风患者 (平均年龄67.3岁,女性49%) 的预期招生.
- 对IAC亚型的标准化评估:亲密,中间,混合和没有.
- 使用修改的兰金尺度 (mRS) 和通过全血细胞计 (CBC) 的炎症标志物评估功能结果.
主要成果:
- 与中介型或混合型相比,患有主要亲密IAC的患者显示RPR水平显著更高.
- 增加的RPR独立地与更高的亲密与中间 (OR=1.53) 和亲密与混合IAC (OR=1.34) 的可能性有关.
- 在缺血性中风 (OR=1.43) 后,较高的RPR水平独立预测了更糟糕的功能结果 (增加的mRS).
结论:
- 升高的RPR与缺血性中风患者的内内动脉化显著相关.
- 较高的RPR水平独立地与缺血性中风后更糟糕的功能结果有关.
- RPR可以作为预测中风严重程度和内脏化的潜在生物标志物.
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