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一个横截面研究来确定Candida spp. 在利比亚运送2型糖尿病患者

Mustafa H M Esmaio¹, Pedro M D S Abrantes¹, Charlene W J Africa¹

¹Maternal Endogenous Infections Studies (MEnIS) Research Laboratories, Department of Medical Biosciences, University of the Western Cape, Bellville, South Africa, uwc.ac.za.

BioMed research international

|January 26, 2026

概括

利比亚的糖尿病患者面临更高的Candida感染风险. 这项研究确定了常见的Candida物种及其抗真菌耐药性,强调了需要进行例行测试以指导治疗的必要性.

科学领域:

医学真菌学医学真菌学
传染性疾病传染性疾病
糖尿病研究研究糖尿病研究

背景情况:

糖尿病患者患有甘菌感染的风险增加了三倍.
利比亚的DM患病率很高 (15.8%),常规真菌鉴定和敏感性测试有限.
口腔角膜炎是糖尿病患者常见的并发症.

研究的目的:

调查利比亚2型糖尿病患者口腔粘膜中Candida物种的流行情况.
为了确定孤立的Candida物种的抗真菌药物耐药性模式.
为了确定Candida携带和患者临床因素之间的关联.

主要方法:

一项涉及182名利比亚2型糖尿病患者口服样本采集的横截面研究.
使用API ID 32 C和VITEK 2 Compact系统对Candida分离物的表型鉴定.
通过磁盘扩散和VITEK AST-YS07卡进行抗真菌敏感性测试,以检测可纳和其他五种药物.

主要成果:

菌携带显示出与临床表现,假牙使用和性别的显著关联.
白虫 (Candida albicans) 是占主导地位的物种 (37.4%),但非白虫 (Candida (NAC)) 物种总体上更为普遍.
大多数隔离物对可纳敏感;然而,在Candida glabrata,Candida guilliermondii和Candida krusei中发现了耐药性. 在一些隔离品中观察到多重药物耐药性.

结论:

新兴的抗真菌耐药性,特别是对某些物种的可纳,需要有针对性的干预措施.
常规的Candida识别和抗真菌敏感性测试对于糖尿病患者的有效的特定物种治疗至关重要.
了解局部耐药性模式对于管理这种高风险人群中的口腔角膜炎至关重要.

关键词:

坎迪达菌的流行率坎迪达菌的流行率对抗微生物药物的监测糖尿病是2型糖尿病的第二种类型.药物耐药性耐药性药物耐药性

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