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Updated: Jan 28, 2026

Noninvasive Intratracheal Lipopolysaccharide Instillation in Mice
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在小鼠的内内灌注后,三循环-DNA反感寡核酸的系统分布

Jérémy Laurent1, Therese B Deramaudt1, Romane Cloix1

  • 1U1179 INSERM, END-ICAP, PHARMAColigo, UFR des Sciences de la Santé-Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France.

NAR molecular medicine
|January 26, 2026
PubMed
概括

内灌注提供了一个安全的替代方案,用于系统输送三循环-DNA反意义寡核酸 (tcDNA-ASOs). 这条肺路线显示出有希望的生物分布和免疫学特征,可用于治疗应用.

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