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Updated: Jan 27, 2026

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METTL14通过m6A调节LRIG1的表达,以影响椎间盘退化的细胞衰老

Ruihai Xiao1,2, Qunying Yang3, Yingqun Yin1,2

  • 1Jiangxi Academy of Medical Science, Jiangxi medical college, Nanchang University, Nanchang, 331000, China.

Journal of orthopaedics
|January 26, 2026
PubMed
概括

作为m6A写字体的METTL14,通过破坏LRIG1mRNA的稳定,增加衰老,促进椎间盘退化 (IVDD). 针对METTL14提供了潜在的IVDD疗法.

关键词:
椎间盘退化症 (IVDD) 是一种疾病.在METTL14中,使用的是METTL14细胞中的核脉 (NP) 细胞.这就是TNF-α.m6ARNA甲基化的过程

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