在英国生物银行队列研究中,疼痛体验的性别差异
Jason Luo1, Mark Woodward1,2, Manuela L Ferreira1
1The George Institute for Global Health (Australia), University of New South Wales, Sydney, NSW, Australia.
British journal of pain
|January 26, 2026
概括
女性比男性更频繁,更严重地经历慢性疼痛,对日常生活产生更深远的影响. 这项大规模的英国生物库研究强调了疼痛条件和经历中持续存在的性别差异.
科学领域:
- 疼痛研究 疼痛研究
- 健康中的性别差异
- 流行病学 流行病学
背景情况:
- 慢性疼痛对女性的影响比男性更大.
- 疼痛感知受到生物,心理和社会因素的影响.
- 了解慢性疼痛的性别差异对于有效管理至关重要.
研究的目的:
- 在英国生物银行 (UK Biobank) 中总结一个全面的疼痛体验问卷.
- 识别和分析慢性疼痛经历中的基于性别的差异.
- 研究男性和女性慢性疼痛的患病率和特征.
主要方法:
- 在2019年管理的128个问题在线自我评估问卷的探索性分析.
- 数据按性别总结.
- 奇平方和t测试用于确定女性和男性之间的统计学上显著差异.
主要成果:
- 超过167,000名英国生物银行参与者回应 (57%为女性).
- 女性报告了较高的慢性疼痛患病率 (60.0%对51.5%) 和14种疾病中的11种疾病的占主导地位,包括骨关节炎,偏头痛和纤维肌痛.
- 与男性相比,女性报告疼痛严重程度更大,持续时间更长,日常功能受损更大.
结论:
- 在慢性疼痛方面,仍然存在显著的性别差异,得到了大样本大小和详细的疼痛表型数据的支持.
- 未来的疼痛调查应该收集性别特定的疼痛状况数据,以更好地了解这些持久的差异.
- 需要进一步的研究来阐明导致慢性疼痛性别差异的潜在机制.
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