补充和凝结级联通路在与艾滋病毒相关的结肠直肠癌中被禁用:蛋白质学研究结果
Shixian Lian1, Lei Li1,2, Yuexiang Yang1
1Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Journal of Cancer
|January 26, 2026
概括
人类免疫缺陷病毒 (HIV) -1 感染会改变结肠直肠癌 (CRC) 蛋白质特征. 艾滋病毒-CRC显示出明显的核糖体上调和补充/凝血级联下调,其中C8B和SERPINA1是潜在的生物标志物.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 癌症生物学 癌症生物学
- 病毒学 病毒学
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 人类免疫缺陷病毒 (HIV) -1 感染与较差的CRC结果有关.
- 了解艾滋病毒对CRC机制的影响至关重要.
研究的目的:
- 为了研究与HIV-1感染相关的结直肠癌 (CRC) 的蛋白质差异.
- 为了确定HIV阳性CRC患者的特定蛋白质表达模式和受影响的途径.
- 为了验证HIV相关CRC的潜在蛋白质生物标志物.
主要方法:
- 协同质量标记 (TMT) 蛋白质组学是在HIV阳性和HIV阴性CRC患者的瘤和相邻的正常组织上进行的.
- 进行了差异性蛋白质表达分析,重点关注HIV特异性变化.
- 用KEGG通路丰富分析来识别显著改变的生物通路.
- 关键的差异表达蛋白 (DEPs) 通过西布洛特和免疫组织化学验证.
主要成果:
- 在与艾滋病毒相关的结直肠癌 (CRC) 中,共发现了592种HIV特异差异表达蛋白 (DEP).
- 上调的核糖体蛋白质 (40) 和下调的补充和凝血级联 (CCC通路;24种蛋白质) 是最显著地改变的通路.
- 证实了关键CCC通路蛋白C8B和SERPINA1的下调,这表明它们具有作为生物标志物的潜力.
结论:
- 与HIV相关的CRC相比,与HIV阴性CRC相比,呈现出独特的蛋白质基因变化.
- 核糖体和CCC通路的失调是HIV-CRC的关键特征.
- C8B和SERPINA1成为艾滋病毒相关结直肠癌的有希望的生物标志物.
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