骨科损伤后产科患者的静脉血栓塞栓症预防:系统性审查
Linnea Fischer1, Erika Ratcliff2, David N Hackney3,4
1Case Western Reserve University School of Medicine, 9501 Euclid Ave, Cleveland, OH, 44106, USA.
Journal of clinical orthopaedics and trauma
|January 26, 2026
概括
骨科骨折的孕妇患者经常接受静脉血栓塞栓症 (VTE) 预防,通常是低分子量肝素. 有限的数据存在于最佳的VTE预防时间和好处在这个人群.
科学领域:
- 产科和妇科 产科和妇科
- 整形外科手术 整形外科手术
- 血液学 血液学 血液学
背景情况:
- 怀孕期间的骨科骨折可能会导致静脉血栓塞栓症 (VTE).
- 孕妇和产后骨折患者的VTE预防的临床实践还没有得到很好的定义.
- 本次审查涉及VTE的风险和当前的预防模式.
研究的目的:
- 确定有骨科骨折的孕妇和产后患者静脉血栓栓塞 (VTE) 的风险.
- 在这个患者群体中检查VTE预防的临床实践模式.
主要方法:
- 在PubMed,Embase,Web of Science和Clinicaltrials.gov搜索了关于怀孕期间骨科骨折和静脉瘤预防的研究.
- 包括来自640项选研究的17篇文章 (案例报告/系列).
- 分析数据使用描述性统计和叙事合成,由于缺乏受控研究.
主要成果:
- 确定了26例产前骨折病例;23例接受了药理性VTE预防 (主要是基于肝素的).
- 预防的持续时间差异很大 (6天到20周).
- 只有一个VTE事件发生在没有接受预防的患者身上;没有报告预防并发症.
结论:
- 药理性静脉动脉瘤预防常用于患有骨科损伤的孕妇患者.
- 孕妇患者在骨科损伤后可能有升高的VTE风险.
- 由于缺乏受控研究,VTE预防的确切益处和最佳持续时间尚不清楚.
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