单细胞/巨介导训练免疫在疾病预防和免疫疗法中
Xiao Zhang1,2, Xinlian Wang1,3, Miaomiao Xu1,4,5,6
1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Bioactive materials
|January 26, 2026
概括
训练有素的免疫力重新编程天生的免疫细胞,如单细胞和巨细胞,以加强防御. 本综述探讨了它们的作用以及纳米材料如何为疾病治疗准训练免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 纳米医学是一种纳米医学.
- 具有天生的免疫力.
背景情况:
- 训练免疫是天生的免疫系统的功能重编程.
- 单细胞和巨细胞是参与训练免疫力的关键免疫细胞.
- 现有的审查往往侧重于分子机制或疫苗诱导的培训.
研究的目的:
- 强调单细胞/巨细胞介导训练免疫的独特作用.
- 探索纳米材料在调节训练免疫力的潜力.
- 为训练免疫的临床转化提供一个框架.
主要方法:
- 审查现有的关于训练免疫力的文献.
- 专注于单细胞和巨细胞的作用.
- 纳米材料应用的讨论.
主要成果:
- 单细胞/巨细胞介导的训练免疫具有不同的中央和外围作用.
- 纳米材料提供精确调节训练免疫力.
- 训练有素的免疫在感染,癌症和炎症中具有治疗潜力.
结论:
- 单细胞/巨细胞训练的免疫对于宿主防御和恒常性至关重要.
- 训练免疫的基于纳米材料的调制打开了新的治疗途径.
- 这个框架支持对各种疾病的临床翻译.
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