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Updated: Jan 28, 2026

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
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Published on: August 6, 2019

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生物相容的蛋白质纳米材料支架用于控制药物输送

Bitopan Boro1,2, Mridusmita Barman1, Rahul Sonkar1,2

  • 1Material Nanochemistry Laboratory, Physical Sciences Division, Institute of Advanced Study in Science and Technology Paschim Boragaon, Garchuk Guwahati 781035 India devasish@iasst.gov.in +91 361 2279909 +91 361 2912073.

RSC advances
|January 26, 2026
PubMed
概括

这项研究开发了与六角化的原-氧酸盐支架,用于药物输送. 增强的支架显示了提高的机械强度,药物加载和持续释放,证明了生物应用的安全性.

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Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
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